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Metabolic Fluid Responsiveness in Children

Recruitingn/aAges 0 Days - 15 YearsAllUniversity Hospital, Bordeaux
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In plain words

What the trial is, and whether it could suit you

The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age less than or equal to 15 years old * Hospitalization in a pediatric intensive care unit after cardiac surgery * Prescription by the attending physician of a fluid expansion of 10ml/kg * Prescription of arterial and venous blood gas before and after the volume expansion to help manage acute circulatory failure * Patient implanted with a functioning arterial line * Patient implanted with a functioning central venous line in the superior vena cava territory Exclusion Criteria: * Patient less than 37 weeks' corrected gestational age * Hemodynamic instability making the delay necessary for any test dangerous * Supine position contraindicated or deleterious * Impairment of echocardiographic acoustic window or restless patient making ultrasonography impossible * Opposition to participate expressed by the patient or by a parent or legal guardian
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What it tests

  • Not listed
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Where

8 sites
Hôpital Louis Pradel - Hospices Civils de Lyon
Bron, France
Hôpital Jeanne de Flandre - CHU de Lille
Lille, France
Hôpital de la Timone - Assistance Publique - Hôpitaux de Marseille
Marseille, France
Hôpital mère-enfant - CHU de Nantes
Nantes, France
Hôpital Necker-Enfants Malades - Assistance Publique - Hôpitaux de Paris
Paris, France
Hôpital Cardiologique Haut Lévêque - CHU de Bordeaux
Pessac, France
Hôpital des enfants - CHU de Toulouse
Toulouse, France
Hôpital Felix Guyon - CHU de la Réunion
Saint-Denis, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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