🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Defining the Human Insulin Resistance Molecular Network; SIGNATURE

RecruitingNAAges 25 Years - 55 YearsAllUniversity of Copenhagen
NCT07255807 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The goal of this intervention study is to learn more about what causes insulin resistance in otherwise healthy adults, and how short-term changes in physical activity or diet may influence it. The study includes healthy male and female participants aged 25 to 55 years, who meet specific health criteria. The main questions it aims to answer are: Does the cause of insulin resistance vary between individuals due to their genes and lifestyle? Can the investigators identify different types (sub-phenotypes) of insulin resistance at the molecular level? Researchers will compare groups who either reduce their physical activity for 14 days or consume a high-fat diet for 3 days, to see how these changes affect insulin sensitivity and related biological markers. Participants will: * Complete a health screening and be assessed for eligibility * Undergo baseline testing to measure insulin sensi

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Age: 25-55 years * Body Mass Index (BMI): 18-30 kg/m² * Healthy (no diagnosed chronic diseases) * Able and willing to comply with study procedures Exclusion Criteria: * Smoking or nicotine use, current or within the past 5 years * Alcohol intake exceeding 10 units per week * Hemoglobin A1c (HbA1c) \> 48 mmol/mol (indicative of diabetes or prediabetes) * Chronic diseases (e.g., cardiovascular disease, diabetes, etc.) * Chronic medication use, including hormonal treatments * High physical activity levels (more than 3 hours per week of moderate to vigorous exercise) * Pregnancy or within 3 months postpartum * Breastfeeding or within 3 months of cessation * Abnormal routine blood markers (as defined in lab screening) * Blood donation within the past 2 months
💊

What it tests

  • Physical Inactivity
  • Hypercaloric High-Fat Diet
📍

Where

1 site
August Krogh Building
Copenhagen, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy