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Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOS

RecruitingNAAges 18 Years - 35 YearsFemaleMst.Sumyara Khatun
NCT07255911 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Does combined Cabergoline and letrozole increase ovulation rate What medical problems do participants have when taking drug Cabergoline and Letrozole ? Researchers will compare drug combination of Cabergoline and letrozole to letrozole alone to see combined cabergoline and letrozole works better as ovulation induction. Participants will: experimental group will receive Cabergoline and Letrozole comparator group will receive letrozole alone TVS Monitoring will be done for 3 cycle for ovarian response

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. PCOS patients diagnosed according to Rotterdam criteria. 2. Age: 18-35 years. 3. Primary or secondary subfertility. 4. Selected for ovulation induction. Exclusion Criteria: 1. Women suffered from PCOS like symptom ex. Late onset congenital adrenal hyperplasia, Cushing syndrome. 2. Serum prolactin (more than 50 ng/ml) (Kyritsi et al., 2018). 3. Male factor infertility. 4. Women with other infertility factors (endometriosis, PID,uterine \& tubal causes of infertility). 5. Uncontrolled Medical disease (DM, HTN, kidney disease, liver disease). 6. History of hypersensitivity to cabergoline \& letrozole. 7. Thyroid dysfunction ( serum TSH ≥5mIU/L) 8. BMI:\< 18.5 kg/m2 and ≥30 kg/m2. 9. Patients on metformin therapy. 10. Patient on antiemetic like Domperidone metoclopramide, antipsychotic drug like haloperidol and risperidone, tricyclic antidepressant like amitriptyline, clomipramine, antihypertensive like verapamil, methyldopa, reserpine.
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What it tests

  • Letrozole 0.5mg
  • Cabergoline 0.5 mg
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Where

1 site
Bangladesh Medical University
Dhaka, Bangladesh
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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