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Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma

Recruitingn/aAges 18 Years - anyAllCentre Hospitalier Universitaire Dijon
NCT07256418 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.

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📋 Eligibility rules (as published)
Inclusion Criteria: FOR PATIENTS WITH SCLERODERMA : * Person who has given written consent * Person with systemic scleroderma FOR CONTROL PARTICIPANTS : * Person who has given written consent * Person undergoing plastic, cosmetic and reconstructive surgery Exclusion Criteria: FOR PATIENTS WITH SCLERODERMA : * Person not affiliated to or not benefiting from a social security scheme * Person subject to a legal protection measure (curatorship, guardianship) * Person subject to a legal protection measure * An adult who is incapable or unable to give consent * Minors FOR CONTROLLED PARTICIPANTS : * Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases * Person not affiliated to or not benefiting from a social security scheme * Person under legal protection (curatorship, guardianship) * Person subject to a legal protection measure * An adult who is incapable or unable to give consent * Minors
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What it tests

  • Skin samples
  • Analysis of fibroblasts
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Where

1 site
CHU Dijon Bourgogne
Dijon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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