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Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication

RecruitingNAAges 20 Years - 40 YearsAllHadeer Maher Mostafa Mohamed
NCT07256561 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms . The outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%. In certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction. Simvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties . The side chain of this material has a single methyl group. It inhi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients had anon contributory medical history. * Patients of age categories between 20 to 40 years old, with no physical disability or psychological problems. * Single rooted teeth with type I root canal anatomy. * Symptomatic cases of failed endodontic treatment with radiographic evidence of periapical bone loss, and the lesion size ranging from 2mm up to 8mm. Exclusion Criteria: * Patients with known sensitivity to the pharmaceutical used in this trial * Patients with former endodontic mishaps (as ledges, transportations, perforations or separated instruments) * Non restorable teeth * Presence of an associated sinus tract. * Advanced periodontal involvement * Teeth representing root fracture. * Pregnant women
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What it tests

  • Simvastatin as an intracanal medication
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Where

1 site
Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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