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Generation of Endometrial Carcinoma Organoids

Recruitingn/aAges 18 Years - anyFemaleRegina Elena Cancer Institute
NCT07258186 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice. Samples will be collected from collaborating extramural facilities, with the aim of analyzing the impact of transport on tissue viability and the success of organoid culture. This study is for exploratory purposes only, without altering the diagnostic and therapeutic pathways of the participants.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 years; * Patients with a histological diagnosis of: endometrial cancer, endometrioid histology, any stage of disease (FIGO I-IV), recurrence/metastasis from endometrial endometrioid cancer, and candidates for surgery and/or hysterectomy; * Written informed consent (study participation and data processing) must be obtained in person and/or through a legal representative/guardian/support administrator/witness, before any study-specific procedure is performed. Exclusion Criteria: * Comorbidities not controlled with adequate medical therapy; * Endometrial cavity infections (pyometra); * Synchronous tumors; * Neoadjuvant treatments; * Previous radiation treatments to the pelvic region.
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What it tests

  • Generation of organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice
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Where

1 site
IRCCS National Cancer Institute "Regina Elena"
Roma, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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