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Menstrual Cycle vs. Oral Contraceptives: Effects on Muscle Protein Metabolism After Resistance Exercise

RecruitingNAAges 18 Years - 40 YearsFemaleUniversity of Toronto
NCT07258576 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The muscles of the body are constantly breaking down old proteins and building new ones. These two processes, protein breakdown and protein synthesis, together are known as protein turnover. Protein turnover is essential for maintaining healthy muscle. Despite its importance, females have historically been underrepresented in protein metabolism research. A long-standing assumption has been that fluctuations in female sex hormones such as estrogen and progesterone, whether across the natural menstrual cycle or in individuals using oral contraceptives (OCs), make metabolism and training responses too variable to study. Because of this, many researchers have excluded female participants for logistical reasons. Resistance exercise, such as weightlifting, is the most effective way to increase muscle size and strength. Each resistance-training session triggers muscle protein synthesis (MPS),

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age: 18-40 years * BMI between 18.5-29.9 kg/m2 (non-obese) * Recreationally active (resistance train minimum twice a week) * Using monophasic or triphasic oral contraceptives for \>1 year (for oral contraceptive users) * Have regular menstrual cycles (21-35 days) for the past 3 months and discontinued any hormonal contraceptive use for at least 6 months (non-oral contraceptive users) * Must meet a progesterone sufficiency test (non-oral contraceptive users) Exclusion Criteria: * Mid-luteal progesterone levels \<16umol * Chronic disease diagnosis (cardiovascular, thyroid, diabetes) * Current or recent remission of cancer * Regular use of non-steroidal anti-inflammatory drugs (NSAIDs; except low-dose aspirin), anticoagulants * Use of prescription drugs that would impact muscle protein synthesis, e.g. Statins, Lithium, ADHD medication. * Insertion of intrauterine device (IUD) - exception: copper * Use of emergency contraception in the last 3 months (e.g. Plan B) * Severe food allergies (e.g. soy, nuts) * Smoking, use of performance enhancing drugs (growth hormones, testosterone)
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What it tests

  • Protein Beverage
  • Stable Isotope Tracer [D5]phenylalanine
  • Stable Isotope Tracer [13C]phenylalanine
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Where

1 site
Goldring Center for High Performance Sport
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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