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Feasibility and Efficacy of rTMS in Depression in Patients With Autism Spectrum Disorder (ASD)

RecruitingNAAges 18 Years - 65 YearsAllHospital Center Guillaume Régnier
NCT07258914 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Depression is a common complication of Autism Spectrum Disorder (ASD): it is four times more prevalent in people with ASD than in the general population. However, treating depression in people with ASD is complicated by the lack of guidelines. Antidepressants appear to be less effective and less well tolerated than in the general population. rTMS (repetitive transcranial magnetic stimulation) is a technique that stimulates the brain in a painless and non-invasive way. This technique is well tolerated and has very few side effects (headaches, fatigue). It is now used routinely in clinical practice to treat resistant depression, with satisfactory results. A few studies using rTMS in depression in people with ASD have shown encouraging results and avenues for improvement. It could therefore be interesting to conduct a therapeutic study with rTMS on depression in people with ASD, followi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient with a diagnosis of ASD validated by a psychiatrist or line 2 * Patient aged 18 to 65... * Patients suffering from EDM (MADRS greater than 20) * No change in treatment in the month prior to inclusion * Patients affiliated with or entitled to social security * Patients who have received informed information about the study and have signed a consent form to participate in the study Exclusion Criteria: * Patients with psychiatric comorbidity (decompensated manic state, schizophrenic disorder) * Pregnancy at the time of inclusion * Patients with contraindications to rTMS and MRI (history of epilepsy, neurological stimulator, pacemaker, cardiac defibrillator, cardiac prosthesis, vascular prosthesis, intracranial clips or clamps, cerebrospinal fluid shunt, metal fragments in the eyes, claustrophobia) * Adults under legal protection (legal guardianship, curatorship, trusteeship), persons deprived of their liberty, persons hospitalised under compulsion (SDT, SDRE).
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What it tests

  • rTMS
  • rTMS treatment with intermittent Theta Burst (ITBS)
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Where

1 site
Centre Hospitalier Guillaume Régnier
Rennes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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