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Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease

Recruitingn/aAges 12 Years - 17 YearsAllKing's College London
NCT07260071 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is: What is the prevalence of hypertension in a population sample of adolescents with ADPKD? Participants will have the following measurements performed: * Height and weight. * Blood pressure. * Non-invasive measurement of arterial stiffness. * Cardiac and renal MRI. * Blood sample. * Genetic testing.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 12 - 17 years at the time of consent * Able to tolerate the key study investigations (office blood pressure measurement, ambulatory blood pressure measurement, MRI and blood test) * Parent with confirmed clinical diagnosis of ADPKD * Parent (if child \<16 years) or both parent and young person (if \>=16 years) consents to genetic testing for ADPKD and demonstrates understanding of the implications of this. Exclusion Criteria: * 18 years or above at the time of study entry * Unable to tolerate key study investigations * Presence of associated co-morbidities which make it difficult to interpret results, including congenital cardiac anomalies and known TSC-PKD1 mutations * Unwilling to undergo genetic testing for ADPKD
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What it tests

  • Not listed
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Where

1 site
Evelina London Children's Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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