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Comparison of Extracorporeal Shock Wave Lithotripsy Versus Retrograde Intrarenal Surgery in the Management of Renal Calculi

RecruitingNAAges 18 Years - 65 YearsAllZiauddin Hospital
NCT07261995 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is being carried out in patients with kidney stones measuring between 1 and 2 centimeters. Kidney stones are common in Pakistan and can cause severe pain, infection, and repeated hospital visits. Two commonly used treatments for stones of this size are extracorporeal shock wave lithotripsy (ESWL) and retrograde intrarenal surgery (RIRS). ESWL uses shock waves applied from outside the body to break the stone into small fragments that can pass in the urine. RIRS is a minimally invasive endoscopic procedure in which a thin flexible scope is passed through the urinary passage into the kidney and a laser is used to break the stone. Adult patients aged 18 to 65 years with a single kidney stone of 1-2 cm will be included. According to the urologist's clinical judgment and patient preference, individuals will undergo either ESWL (Group A) as a day-care shock wave procedure or RIRS (G

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 18 and 65 years. * Patients diagnosed with a single renal calculus measuring between 1 cm and 2 cm, confirmed on imaging (ultrasound or non-contrast CT KUB). Exclusion Criteria: * Presence of multiple renal stones or bilateral renal stones. * Patients with anatomical abnormalities such as horseshoe kidney, ureteropelvic junction obstruction, or calyceal diverticulum based on medical history or radiological findings. * Active urinary tract infection at the time of intervention. * Pregnant women. * Patients with bleeding disorders or on anticoagulation therapy that cannot be safely stopped. * Patients with chronic kidney disease (eGFR \< 30 mL/min/1.73 m²). * Patients with morbid obesity (BMI \> 40 kg/m²). * Patients with solitary kidney.
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What it tests

  • Extracorporeal Shock Wave Lithotripsy (ESWL)
  • Retrograde Intrarenal Surgery (RIRS)
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Where

1 site
Ziauddin Hospital
Karachi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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