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Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy

RecruitingNAAges 21 Years - 65 YearsAllCairo University
NCT07262242 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Opioids are widely used during anesthesia for pain control, but they cause many side effects-such as nausea, constipation, respiratory depression, dependence, and delayed recovery. They can also worsen low blood pressure in patients with unstable circulation. Because of these risks, multimodal analgesia is recommended to reduce opioid use. Research on other non-opioid options is limited. Systemic lidocaine offers anti-inflammatory and opioid-sparing benefits and improves recovery in elective colorectal surgery, but its role in emergency laparotomy is still unclear and requires further study.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (21-65 years), ASA I-III undergoing emergency laparotomy with midline incision Exclusion Criteria: * Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions) * Patients on vasopressor infusion, patients with high shock index (heart rate / systolic blood pressure \>1) * Body mass index \<18 or \> 35 Kg/m2, * Pregnant or lactating women, * Allergy of any of the study drugs * Severe liver cell failure and renal impairment by history and/or abnormal liver and kidney function tests.
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What it tests

  • Lidocaine (drug)
  • Fentanyl (IV)
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Where

1 site
Kasr Alainy Hospital
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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