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Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study

RecruitingNAAges 40 Years - 69 YearsAllNantes University Hospital
NCT07263113 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses. Recent evidence suggests a possible link between severe periodontitis and cardiovascular diseases through shared inflammatory pathways. The PAROCAR study aims to evaluate the association between generalized periodontitis (stages 3 and 4, 2017 Chicago Classification) and arterial stiffness measured by pulse wave velocity (PWV), compared to matched controls without periodontitis, adjusted for conventional cardiovascular risk factors.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 40-69 years * Minimum of 12 teeth (3 per quadrant) * Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium Exclusion Criteria: * Patients diagnosed with diabetes, * Patients diagnosed with hypertension or with a history of severe cardiovascular disease, * Patients diagnosed with familial hypercholesterolaemia, * Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results, * Patients with a BMI ≥ 30 kg/m², * Patients who have previously undergone periodontal treatment, * Patients who consume more than 2 units of alcohol per day, * Patients who refuse to participate in the study, * Minors and patients under the age of 40, * Adult patients under legal protection (guardianship, curatorship), * Patients deprived of their liberty, * Pregnant or breastfeeding women, * Patients not affiliated with a health insurance scheme (AME) * Patients already included in another interventional study
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What it tests

  • Periodontal examination and pulse wave velocity
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Where

1 site
CHU de Nantes
Nantes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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