Improving Treatment for Depression in General Practice Using a Step-by-Step Care Plan.

Inclusion Criteria: 1. The participant must be referred to the study with a diagnosis of unipolar depressive disorder, as judge by the GP. 2. Severity of the depressive episode corresponding to moderate depression, as judged by the GP. 3. Clinical uncertainty regarding which of the treatments, medication or psychotherapy, would be the better choice in the case concerned. 4. Age criteria: Participants must be at least 18 years old and no more than 65 years old at the time of randomisation. 5. The participant must be a patient in general practice. 6. Participants must be able to participate in virtual meetings (e.g. by phone or computer) and have e-Boks. 7. The participant must be willing to receive psychotherapy by a psychologist and/or medication. 8. Must have signed the document of informed consent. Exclusion Criteria: 1. Misuse of substances that might influence the study, as judged by the investigator. 2. Difficulty in understanding the Danish language, as judged by the investigator. 3. A diagnosis of dementia. 4. Medical conditions that might interfere with the study outcome or safety, judged so by the investigator. 5. Pregnancy. 6. High risk of non-adherence at the investigator's discretion. 7. Suicidality: according to C-SSRS with a positive response to question 4 or 5 within the last three months or upon investigator's discretion. 8. No current medical or psychotherapy treatment initiated within the last 4 weeks prior to screening.