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Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery

RecruitingNAAges 18 Years - 80 YearsAllFudan University
NCT07264556 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Adult patients aged 18-80 years old, American Society of Anesthesiologists physical status I-III, who were scheduled for elective colorectal cancer surgery under general anesthesia were recruited for this study. They were randomized to receive opioid-free anesthesia (OFA), opioid-sparing anesthesia (OSA) and opioid-based anesthesia (OA) group. Blood samples were collected pre-surgery and 24h post-surgery. As primary endpoint, serum neutrophil myeloperoxidase (MPO) and citrullinated histone3 (CitH3) was measured. The secondary endpoints included the effects of postoperative serum on colorectal cancer (CRC) cells malignancy, numerical rating scale (NRS) scores, postoperative adverse events and recovery profiles. For OA group, intraoperative remifentanil and sufentanil were used and postoperative patient controlled intravenous analgesia (PCIA) was performed with 0.5ฮผg/ml of sufentanil and

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * aged 18-80 years old, * American Society of Anesthesiologists physical status I-III, * elective colorectal cancer surgery under general anesthesia Exclusion Criteria: * previous history of colorectal surgery, * addicted to opioids, * serious major mental or physical illness (heart, pulmonary, hepatic, or renal diseases), * radiotherapy or chemotherapy history within 8 weeks prior to the surgery, * contraindications to anesthetic agents or epidural.
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What it tests

  • OA strategy
  • OSA stategy
  • OFA strategy
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Where

1 site
Fudan University Shanghai Cancer Center
Shanghai, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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