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Early Prediction of Lung Injury in Preterm Infants Score

Recruitingn/aAges 26 Weeks - 32 WeeksAllFondazione IRCCS Policlinico San Matteo di Pavia
NCT07265583 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main hypothesis is that even preterm infants considered "stable" receiving non-invasive ventilation may be at risk of developing BPD due to an inhomogeneous distribution of ventilation. Identifying this characteristic from the first days of life by using EIT could, in the future, optimize non-invasive ventilation strategies as early as possible, such as lung recruitment manoeuvres, which are currently mainly used during invasive mechanical ventilation. In addition, comparing the LUS scores and homogeneity parameters derived from the EIT may help to further confirm the role of semi-quantitative lung ultrasound as a rapid, non-invasive, and readily available tool in NICUs for monitoring the lung function of preterm infants in the short and long term. The primary objective is to measure homogeneity by Electrical Impedance Tomography (EIT) technology, used in the first weeks of life, fo

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📋 Eligibility rules (as published)
Inclusion Criteria: preterm infants born between 26 and 32 weeks of gestational age and/or with a birth weight \< 1500g (very low birth weight infants - VLBW) with respiratory distress syndrome (RDS). \- Exclusion Criteria: - outborn infants * complex congenital malformations * metabolic, chromosomal, or other genetic abnormalities * pulmonary hypoplasia, congenital anomalies of surfactant proteins or other pulmonary abnormalities * any skin anomalies * need for mechanical ventilation \> 72h after birth * any life-threatening comorbidity or any other medical condition which, in the opinion of the investigator, makes the patient unsuitable for inclusion. * lack of parent consent.
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What it tests

  • Not listed
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Where

1 site
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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