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Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery

RecruitingNAAges 18 Years - anyAllRegion Skane
NCT07267546 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Most cardiac surgery procedures requires the use of heart-lung machine. The heart-lung machine circuit needs to be filled with a fluid before connecting it to the patients circulation. This is called priming and is accomplished by filling the circuit with a solution used for fluid replacement. The circuit in our institution requires 1100 mL to be filled. The body has several mechanisms with the purpose to maintain its state of balance. When a large amount of clear solution suddenly enters the blood stream this balance can be altered. The goal of this clinical trial is to investigate different priming solutions in the heart-lung machine circuit. The main questions it aims to answer are: How do different priming solutions alter the acid-base balance, osmolality and electrolytes which reflects the body's water balance for patients undergoing cardiac surgery with the use of heart-lung mach

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients 18 years and above * Undergoing coronary artery bypass graft (CABG) surgery as single surgery * Undergoing aortic valve replacement (AVR) as single surgery (AtriClip is allowed) * Given consent to participate, both verbal and written Exclusion Criteria: * Subnormal heart function (defined as an ejection fraction \<45%), and no signs of heart failure (edema). * Body weight \<60 kg or \>120 kg * Preoperative hemoglobin \<120 g/L, * Subnormal kidney function (defined as GFR \<30 ml/min), * Blood sodium outside normal range (135-145 mmol/l), * Need of acute surgery * AVR due to aortic valve insufficiency * Changes in operating method or addition of intraoperative procedures.
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What it tests

  • Ringer's Acetate 80
  • Plasmalyte
  • Ringer's Acetate no add
  • Ringer's Acetate 160
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Where

1 site
Skane University hospital
Lund, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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