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Unravelling the Measles Paradox (MISIA)

Recruitingn/aAges 18 Years - anyAllErasmus Medical Center
NCT07267585 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The measles (MeV) paradox refers to an apparent contradiction: natural measles causes a transient but profound immune suppression putting patients at risk for opportunistic infections for years, while at the same time MeV infection induces robust immune activation leading to lifelong protection against measles. In this protocol, we test our hypothesis that natural measles causes immune amnesia by altering the composition of circulating immune memory cells. In comparison to the prior studies performed during the 2013 outbreak, we will specifically determine \[1\] to what extent pre-existing immunity is reduced, \[2\] for how long this functional immune suppression can be detected, and \[3\] to what extent MeV-specific immune cells expand. Recently, the WHO reported a 30-fold increase of the number of measles cases in the European Region in 2023 and the ECDC has published a threat assessm

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📋 Eligibility rules (as published)
Inclusion Criteria: Cohort A * 18 years or older * No known history of measles or vaccination * Decided to take MMR vaccination before the upcoming measles outbreak Cohort B * 18 years or older * No known history of measles or vaccination (seronegative confirmed) * Contracted measles during the upcoming outbreak Cohort C * 18 years or older * No known history of measles or vaccination (seronegative confirmed) Cohort D * 18 years or older * Experienced measles during the 2013 outbreak Cohort E * 18 years or older * Received second dose of measles vaccines ±10 years ago Exclusion Criteria: A potential participant who meets any of the following criteria will be excluded from the study: * Diagnosed chronic disease * Immune suppression (due to medication or underlying disease) * Additionally for subjects recruited to Cohort A: * pregnant women or women planning to get pregnant in less than one month after the start of the study. This is a precaution; the MMR vaccine is not recommended for pregnant women. * People who have had a severe allergic reaction (e.g., anaphylaxis) after a previous vaccination.
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What it tests

  • Not listed
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Where

1 site
Erasmus MC
Rotterdam, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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