Camrelizumab and Apatinib With or Without FOLFOX Chemotherapy for Advanced HCC

Inclusion Criteria: 1. Patients volunteered to participate in this study and signed informed consent; 2. ≥18 years old, male and female; 3. Before treatment, it was confirmed by histopathology or cytology, or clinically diagnosed as hepatomegaly.Patients with Hepatocellular Carcinoma, HCC); 4. BCLC stage B or C hepatocellular carcinoma, which is not suitable for curative surgical or local therapies, or has progressed after such treatments. 5. Local therapy (including but not limited to surgery, radiation therapy, transarterial chemoembolization \[TACE\], hepatic arterial infusion, radiofrequency ablation, cryoablation, or percutaneous ethanol injection) must have been completed at least 4 weeks prior to the baseline radiographic scan (with the exception of palliative radiotherapy, for which a 2-week interval is sufficient)." 6. Has not received any systemic treatment for HCC. 7. According to RECIST 1.1 standard, patients have at least one measurable lesion (CT/MRI scan long diameter ≥10mm or CT/MRI scan short diameter ≥15mm for lymph node lesions, and the lesion has not received radiotherapy, freezing or other local treatments); 8. Child-pugh liver function grading: Grade A or Grade Better B (≤7 points) 9. ECOG PS score 0-2; 10. Expected survival ≥ 12 weeks; 11. Major organ functions are basically normal and meet the following requirements (within 7 days before starting the study treatment): 1. Complete blood count: absolute neutrophil count ≥ 1.5\*10\^9/L, platelets (PLT) ≥ 75\*10\^9/L, hemoglobin ≥ 90 g/L; 2. Blood biochemistry: albumin ≥ 25 g/L; total bilirubin ≤ 3.0 × upper limit of normal (ULN); alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) ≤ 5 × ULN; creatinine (Cr) ≤ 1.5 × ULN or creatinine clearance (CrCl) \> 50 mL/min. 3. International normalized ratio (INR) ≤ 2.3 or prothrombin time (PT) no more than 6 seconds above the normal control range; 4. Urine protein \<2 (if urine protein ≥2, a 24-hour urine protein quantification can be performed; 24-hour urine protein \<1.0 g is allowed for inclusion). 12. Patients with active hepatitis B virus (HBV) infection must receive anti-HBV therapy prior to initiating study treatment and be willing to continue antiviral therapy throughout the study; hepatitis C virus (HCV) RNA-positive patients must receive antiviral therapy according to local standard treatment guidelines with liver function not exceeding CTCAE grade 1 elevation. 13. Women of childbearing potential should have a negative serum or urine pregnancy test within 7 days prior to study enrollment, must not be breastfeeding, and must agree to use contraception during the study and for 6 months after the study; men must agree to use contraception during the study and for 6 months after the study. \- Exclusion Criteria: 1. Known cholangiocarcinoma, sarcomatoid HCC, mixed cell carcinoma, and fibrolamellar carcinoma; having other active malignancies within the past 5 years or simultaneously, excluding HCC. Successfully treated localized tumors, such as basal cell carcinoma of the skin, squamous cell carcinoma of the skin, superficial bladder cancer, prostate carcinoma in situ, cervical carcinoma in situ, breast carcinoma in situ, etc., can be included. 2. Patients who are preparing for or have previously undergone organ or allogeneic hematopoietic stem cell transplantation; 3. Patients with clinical symptoms of moderate to severe ascites that require therapeutic puncture or drainage; uncontrolled pleural effusion or pericardial effusion of moderate amount or more; 4. Patients with a history of gastrointestinal bleeding within 6 months before the start of the study treatment or a clear tendency for gastrointestinal bleeding, such as: high-risk or severe esophageal and gastric varices, localized active gastrointestinal ulcer lesions, or persistent positive fecal occult blood; 5. Patients who have had abdominal fistulas, gastrointestinal perforation, or intra-abdominal abscesses within 6 months before the start of the study treatment; 6. Patients with known hereditary or acquired bleeding disorders (such as coagulation dysfunction) or thrombophilia. 7. Currently using or having recently used (within 10 days before the start of the study treatment) aspirin \[\>325 mg/day (maximum antiplatelet dose)\] or dipyridamole, ticlopidine, clopidogrel, and cilostazol; 8. Occurrence of thrombotic or embolic events within 6 months before the start of the study treatment, such as cerebrovascular accidents (including transient ischemic attack, cerebral hemorrhage, cerebral infarction, pulmonary .embolism). 9. Uncontrolled cardiac clinical symptoms or conditions, such as: 1. Heart failure of NYHA class II or above; 2. Unstable angina; 3. Myocardial infarction occurring within the past year; 4. Clinically significant supraventricular or ventricular arrhythmias requiring medical intervention; 5. Patients with hypertension whose condition is poorly controlled by medication and who are assessed by a doctor to be at high risk when using apatinib; 10. Suffering from hypertension that cannot be well controlled with antihypertensive medication (systolic ≥140 mmHg or diastolic ≥90 mmHg); history of hypertensive crises or hypertensive encephalopathy; 11. Major vascular disease occurring within 6 months prior to the start of study treatment (e.g., an aortic aneurysm requiring surgical repair or recent peripheral arterial thrombosis); 12. Severe, non-healing, or dehisced wounds, as well as active ulcers or untreated fractures; 13. Undergoing major surgery (except for diagnosis) within 4 weeks before the start of study treatment or anticipated need for major surgery during the study period; 14. Inability to swallow pills, malabsorption syndrome, or any condition affecting gastrointestinal absorption; 15. History of intestinal obstruction and/or clinical signs or symptoms of gastrointestinal obstruction within 6 months before sta