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Impact of a Pro-diversity Gut Microbiota Diet After a Bariatric Surgery on Gut Microbiota, Eating Behaviour and Sensory Function

RecruitingNAAges 25 Years - 65 YearsAllHospices Civils de Lyon
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In plain words

What the trial is, and whether it could suit you

Bariatric surgery is the most effective treatment for long-term weight loss and reducing obesity-related health risks. It alters the gastrointestinal tract as well as metabolic and hormonal functions, influencing eating behaviour. However, weight loss outcomes and long-term maintenance vary between patients, likely due to changes in the gut microbiota. Dietary recommendations aimed at improving microbiota diversity could help support sustained weight loss after surgery. The BariaGut Taste study aims to compare two dietary approaches following bariatric surgery: nutritional counselling promoting gut microbiota diversity versus standard nutritional counselling. One year after surgery, the study will evaluate differences in microbiota diversity, changes in food preferences and eating behaviours, sensory profiles (taste, smell), levels of digestive and gut hormones fasting, before and after

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Between 25 and 65 years old * Undergoing either sleeve gastrectomy or Roux-en-Y gastric bypass * With grade 3 obesity (BMI≥40 kg/m²) or with BMI≥35 kg/m² and at least one comorbidity likely to be improved after surgery, with the exception of type 2 diabetes * Signed consent form * Living less than an hour and 30 minutes from the hospital * Presence of effective and stable contraception for women of childbearing potential Exclusion Criteria: * Type 2 diabetes * Presence of a contraindication to bariatric surgery * Presence of gastrointestinal pathologies with an inflammatory component, known gastroparesis, total gastrectomy, colectomy, exocrine pancreatic insufficiency, known endocrine pathologies inducing hyperglycaemia (uncontrolled dysthyroidism, acromegaly, hypercorticism, etc.), severe chronic renal insufficiency (\< 30mL/min), or hepatocellular insufficiency * Claustrophobic * Pregnant or breastfeeding women * Taking an obesity treatment 3 months before surgery * Taking a corticoids, immunosuppression, anabolizing, or growing hormones, antibody treatments less than 3 months before inclusion * Daily taking of laxatives or drugs that can strongly interfere with the composition of the intestinal microbiota. If taken sporadically, the patient can be included at a distance (3 weeks) from the laxatives taken. * Specific diets (vegetarian, vegan or without gluten) * No French speaker * Already included in other study * Donated blood in the last two months * Without freezer access * With allergy or intolerance to food propose in ad libitum buffet
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What it tests

  • Nutritional counseling
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Where

3 sites
Hospital Edouard Herriot, digestive surgery department
Lyon, France
Centre de recherche en nutrition humaine de Rhône-Alpes
Pierre-Bénite, France
Hôpital Lyon sud, Endocrinology Diabetes Nutrition department
Pierre-Bénite, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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