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Real-World Effectiveness of Aztreonam-Avibactam Against MBL-Producing CRE

Recruitingn/aAges 18 Years - anyAllSir Run Run Shaw Hospital
NCT07268560 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Why This Study is Needed Some bacterial infections have become resistant to common antibiotics, making them very difficult to treat. This is a growing and serious health problem. A new combination drug, Aztreonam-Avibactam (we'll call it ATM-AVI), has been developed to fight these tough bacteria. This new drug was recently approved for use in Europe (April 2024), the United States (February 2025), and China (June 2025). Because it is so new, there is very little information available, especially in China, on how well it works for real patients outside of initial testing. This lack of real-world experience means we don't know enough about: * How effective it is for typical patients in China. * The types of patients and infections it is used for. * How it affects a patient's time in the hospital. This study aims to fill these gaps by looking at how ATM-AVI performs in Chinese hospitals,

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📋 Eligibility rules (as published)
Inclusion Criteria: * 1\. Age 18 years or older 2. Hospitalized with a diagnosis of confirmed cIAI or HAP/VAP 3. Confirmed infection with MBL-producing CRE 4. Received on label use of ATM-AVI treatment for ≥24 hours 5. Informed consent will be obtained or waived. Exclusion Criteria: * 1\. Confirmed or suspected infection caused by Gram-negative species not expected to respond to ATM-AVI 2. Currently enrolled in an interventional clinical tria
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What it tests

  • Aztreonam-Avibactam
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Where

2 sites
The First Affiliated Hospital of Nanchang University
Nanchang, China
Sir Run Run Shaw Hospital
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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