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Free Vitamin D and Steroid Metabolism in Endocrine Disorders

Recruitingn/aAges 18 Years - anyAllUniversitaire Ziekenhuizen KU Leuven
NCT07268742 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical study aims to gain a better understanding of how different forms of vitamin D are processed in the body in healthy individuals, pregnant women, and patients with various hormonal (endocrine) and kidney (renal) disorders. In the long term, this study may provide new insights that could how vitamin D is tested and interpreted in these groups. Vitamin D has several important roles in the body, such as building strong bones and maintaining calcium balance in the blood. Most vitamin D in the blood circulation is attached/bound to a protein called "vitamin D binding protein" (VDBP), which makes it unavailable for the body to use. A much smaller portion circulates freely in the blood and this is called "free vitamin D". This free form can be directly used by the body. When your doctor tests your vitamin D levels, this usually refers to total vitamin D (the sum of bound and free

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📋 Eligibility rules (as published)
1. General inclusion Criteria: \- 18 years or above 2. General exclusion Criteria: * Below 18 years of age * Individuals incapable of providing informed consent 3. Cohort inclusion criteria * Obesity: BMI ≥ 25 kg/m2 * Chronic Kidney Disease: ≥ CKD stage 3a (eGFR \< 60 mL/min/1.73m2) * Pregnancy: in trimester 1 of pregnancy * Primary hyperparathyroidism: diagnosis at UZ Leuven and scheduled for parathyroidectomy at UZ Leuven * Complex calcium and phosphate disorders: diagnosis at UZ Leuven 4. Cohort exclusion criteria * Healthy controls: BMI below 18 kg/m² or above 25 kg/m², pregnancy, chronic kidney disease (independent of staging), primary hyperparathyroidism and vitamin D and/or calcium supplementation * Obesity: chronic kidney disease (independent of staging), pregnancy, primary hyperparathyroidism * Chronic Kidney Disease: BMI below 18 kg/m² or above 30 kg/m², pregnancy, primary hyperparathyroidism * Pregnancy: BMI below 18 kg/m² or above 30 kg/m², chronic kidney disease (independent of staging), primary hyperparathyroidism * Primary hyperparathyroidism: BMI below 18 kg/m² or above 30 kg/m², pregnancy, chronic kidney disease (independent of staging), secondary hyperparathyroidism
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What it tests

  • Blood draw for the laboratory assessment
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Where

1 site
University Hospitals Leuven
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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