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Heartburn, Gastroesophageal Reflux Disease

RecruitingPhase 4Ages 19 Years - anyAllIncheon St.Mary's Hospital
NCT07268820 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Gastroesophageal reflux disease (GERD) is a condition caused by the reflux of stomach contents into the esophagus, presenting with typical symptoms such as heartburn and acid regurgitation. GERD is a chronic condition that affects quality of life, and patients with this condition are known to have a lower quality of life compared to healthy individuals. In particular, nocturnal heartburn can lead to sleep deprivation and affect daily life, as well as overall quality of life. This study aims to evaluate the efficacy of alleviating nocturnal heartburn symptoms in patients with erosive reflux disease (ERD).

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Korean adults aged 19 years or older as of the date of written consent 2. Those diagnosed with erosive gastroesophageal reflux disease based on upper gastrointestinal endoscopy (EGD) 3. Those who reported nighttime heartburn for more than 3 months at the time of screening (Visit 1) 4. Those who voluntarily decided to participate and provide written informed consent Exclusion Criteria: 1. Those who cannot undergo upper gastrointestinal endoscopy (EGD) 2. Individuals with a history of drug or alcohol abuse (within the past year) 3. Individuals who have received other investigational products within one month prior to the screening visit (Visit 1) 4. In addition to the above, individuals with clinically significant findings that the investigator deems medically inappropriate for the present study
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What it tests

  • Zastaprazan
  • Esomeprazole
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Where

10 sites
Korea University Ansan Hospital
Ansan, South Korea
Pusan National University Hospital
Busan, South Korea
Kyungpook National University Chilgok Hospital
Chilgok, South Korea
Hallym University Chuncheon Sacred Heart Hospital
Chuncheon, South Korea
Chonnam National University Hospital
Gwangju, South Korea
Catholic University of Korea, Incheon ST. Mary's Hospital
Incheon, South Korea
Gangnam Severance Hospital
Seoul, South Korea
Kyung Hee University Hospital
Seoul, South Korea

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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