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Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil

RecruitingNAAges 18 Years - 65 YearsAllUniversiti Sains Malaysia
NCT07269093 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars? Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies. Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to: * apply the topical application on their scar twice a day for 8 weeks * attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs * immediately inform the researcher if they experience any side effects

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with traumatic or surgical wounds which have healed by primary intention within 14 days * Length of scar at least 3cm Exclusion Criteria: * Patients with seafood allergy * Patients with scar from wounds that were complicated by infection or wound breakdown * Patients who have undergone scar treatment by other modalities * Patients with history of keloids / hypertrophic scars * Pregnant patients
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What it tests

  • Chitosan cream
  • Silicone Gel
  • Olive Oil Topical Oil
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Where

3 sites
Hospital Raja Perempuan Zainab II
Kota Bharu, Malaysia
Hospital Pakar Universiti Sains Malaysia
Kubang Kerian, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, Malaysia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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