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A Prospective, Single-arm, Open-label Clinical Trial to Evaluate the Efficacy and Safety of Ivarmacitinib in the Treatment of Palmoplantar Pustulosis

RecruitingNAAges 18 Years - anyAllXijing Hospital
NCT07270003 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

What's the problem? Palmoplantar pustulosis (PPP) is a long-term skin condition that mainly affects the palms of hands and soles of feet. It causes red, scaly skin with small, non-infectious blisters (called pustules), and often brings pain, itching, or even joint damage over time. It's more common in women aged 40-58 and makes daily life harder. Right now, treatments for PPP aren't great. Creams (like corticosteroids) make symptoms come back fast. Pills (such as acitretin) work slowly, don't always help, and can have bad side effects. Some strong injectable drugs (biologics) are expensive, need long-term use, and require regular checks for infections-plus they don't work well for many PPP patients. What's this study trying to do? This study will test a new pill called ivarmacitinib to see if it works for PPP, and if it's safe. Here's what researchers want to find out: Does ivarmaciti

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * โ‰ฅ18 years old; clinically/pathologically confirmed PPP; failure/intolerance to โ‰ฅ1 conventional systemic therapy (12-24 weeks of standard dosing); physician-judged suitability for ivarmacitinib; signed informed consent. Exclusion Criteria: * Lymphocyte count \<0.5ร—10โน/L, neutrophils \<1ร—10โน/L, platelets \<100ร—10โน/L, or hemoglobin \<80g/L; serum creatinine \>132.6ฮผmol/L, AST/ALT \>2ร—ULN, or total bilirubin \>2.0mg/dL; active infections (tuberculosis, hepatitis B/C, systemic candidiasis); other conditions hindering participation or data interpretation.
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What it tests

  • Ivarmacitinib
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Where

1 site
Xijing hospital
Xi'an, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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