💬In plain words
What the trial is, and whether it could suit you
The research study is considering a non-invasive way to measure the percentage of fat in the liver using ultrasound. This could help detect early signs of a very common condition called metabolic dysfunction-associated steatotic liver disease (MASLD). Current tests, like MRI or biopsy, can be expensive or invasive. If successful, this ultrasound tool could become an easier and more accessible way to monitor liver health - especially for people with obesity, diabetes, high blood pressure, or high cholesterol.
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
Diseased subject:
* Adult patients (age 18 - 75 years)
* Consent to participate in the study
* Diagnosed or suspected MASLD from the hepatology clinic, OR
* High-risk population meeting the adult cardiometabolic criteria (defined as the presence of at least one of the following: diabetes, obesity (BMI ≥ 25 kg/m2), hypercholesterolemia, and hypertension)
Healthy volunteer:
* Adult patients (age 18 - 75 years)
* Consent to participate in the study
* No suspicion of MASLD by laboratory/imaging/clinical examinations
* Absence of known pre-existing conditions (metabolic syndrome, diabetes mellitus, obesity, insulin resistance, dyslipidemia, etc.)
Exclusion Criteria:
* Pregnancy or nursing.
* Contraindications to MRI including, but not limited to, severe claustrophobia, pacemaker, or existing metallic/mechanical implant(s).
* Acute illness/cognitive impairment resulting in an inability to cooperate with the MRI and ultrasound breath-holding instructions.
* BMI \> 35 kg/m2
* History of excessive alcohol consumption according to the updated MASLD criteria (\>2 drinks/day OR \>210 grams/week for males AND \>1 drink/day OR \>140 grams/week for females) or drug use over the past 2 years.
* Known acute or chronic hepatitis; or other etiology of liver disease.
* Presence of known congenital hepatic anomaly.
* Known cirrhosis
* Known active cancer
💊
What it tests
- Verasonics NXT Data Acquisition System
- Philips EPIQ Elite
- EchoSense FibroScan
- Philips 3T Ingenia Elition
University of Washington
Seattle, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
HealthTeky