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Exercise in Perimenopause to Improve Cognitive Health

RecruitingNAAges 40 Years - 55 YearsFemaleUniversity of British Columbia
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In plain words

What the trial is, and whether it could suit you

Perimenopause is now considered a possible risk factor for dementia and may contribute to the fact that 2/3 of those living with Alzheimer's disease are females. Indeed, research studies show that middle-aged females demonstrate significant declines in their thinking abilities and detrimental changes in their brains as they go through perimenopause. Thus, perimenopausal females need strategies to bolster their brain health. The World Health Organization strongly recommends physical activity interventions to reduce the risk of decline in thinking abilities. However, whether exercise can improve thinking abilities and brain health in perimenopausal females has not been examined. Our research aims to address this important knowledge gap in female brain health. We will study the effects of a 6-month resistance exercise training (e.g., lifting free weights, exercise with weight machine) pro

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Are biological females, as assigned at birth * Are aged between 40 and 55 years * Had at least 1 menstrual period in the last 10 months * Are perimenopausal based on STRAW +10 Staging System, or answer "yes" to MQ6 questions of changes in periods, having hot flashes, or vaginal dryness, pain, or sexual concerns * Have an intact uterus * Have a Montreal Cognitive Assessment (MoCA) score \>=26/30 for in-person or \>=19/22 for telephone , indicating normal cognition * Have subjective cognitive complaints defined as responding "yes" to "Do you feel like your memory or thinking is becoming worse?" * Completed high school education * Read and speak English with acceptable visual and auditory acuity * Are able to safely engage in moderate-intensity PRT as indicated by the PAR-Q+; and * Are able to provide informed consent. Exclusion Criteria: * Are engaged in regular PRT (i.e., 2x/week) in the prior three months * Are diagnosed with cognitive impairment or dementia of any type * Are at high risk for cardiac complications during exercise * Have clinically important peripheral neuropathy or severe musculoskeletal or joint disease that impairs mobility * Are taking medications that negatively affect cognitive function, such as anticholinergics, major tranquilizers, and anticonvulsants * Have a BMI \<15 or anorexia nervosa; g) had surgical menopause * Had endometrial ablation that resulted in the loss of menstruation * Have polycystic ovarian syndrome * Currently undergoing chemo * Are using estrogen-containing contraception in the last 12 months * Had premature ovarian failure; or * Are already enrolled in a drug or exercise trial
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What it tests

  • Progressive Resistance Training
  • Balance, Flexibility, and Tone Exercises
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Where

1 site
University of British Columbia
Vancouver, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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