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Effects of tVNS and mCIMT in Chronic Stroke

RecruitingNAAges 50 Years - 75 YearsAllRiphah International University
NCT07272239 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Stroke is a leading cause of death and disability worldwide, resulting in significant physical and cognitive impairments. Arm weakness is most common after stroke and its treatment is recognized as an area of considerable need. The functional limitations and disabilities experienced by stroke survivors, particularly in the upper limb have a profound impact on their quality of life. Current treatment for arm weakness typically comprises intensive, task-specific and repetitive rehabilitative interventions. Transcutaneous auricular vagus nerve stimulation (tVNS) is a novel noninvasive treatment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve. This study determines the effects of Vagus Nerve Stimulation and Modified Constraint Induced Movement Therapy on Motor Function, Cognition, and Quality of life in chronic stroke patients. This randomized clinical

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📋 Eligibility rules (as published)
Inclusion Criteria: * Both male and female patients are included in the study. * Left sided ischemic stroke patients. * Patients with chronic, moderate-severe upper limb hemiparesis (\>6 months-2 years) * Stable participants having a stroke severity score \> 6 on National Institute of Health Stroke Scale (NIHSS). * Montreal Cognitive Assessment (MoCA) score ≥26. Exclusion Criteria: * Participants who show the symptoms of global or receptive aphasia. * Participants who have a history of significant neurological or psychiatric disorders, other than stroke, that could interfere with upper limb motor or sensory recovery. * Modified Ashworth scale score ≥ 3 of the affected upper extremity. * Patients who are not able to sit with or without support. * Patients with severe apraxia, somatosensory problems. * Resting heart rate (\< 50 beats/min). * Participants who are currently participating in another clinical trial or research study.
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What it tests

  • Transcutaneous Vagus Nerve Stimulation
  • Modified Constraint Induced Movement Therapy with Routine Physical Therapy
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Where

2 sites
Al- firdous physiotherapy clinic
Rawalpindi, Pakistan
IIMCT- Railway General Hospital
Rawalpindi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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