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Comparison of the Resection Site Order in Simultaneous Approach of Colorectal Liver Metastasis

Recruitingn/aAges 18 Years - anyAllAzienda Ospedaliera SS. Antonio e Biagio e Cesare…
NCT07272928 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Colorectal cancer frequently presents with liver metastases, and complete removal of both primary and liver tumors can significantly improve survival. Simultaneous resection (SA) of the colon and liver is increasingly used and is considered safe when minor liver resections are performed, offering advantages such as shorter hospitalization, fewer complications, and faster chemotherapy initiation. However, the best sequence of resection, liver-first or colon-first, remains uncertain, as each has potential benefits and drawbacks, particularly regarding anastomotic healing. Minimally invasive approaches to SA show similar outcomes to open surgery, though limited data suggest that resection order may affect blood loss.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients diagnosed with colorectal cancer with synchronous liver metastases during the reference period, who underwent simultaneous resection. Exclusion Criteria: * Simultaneous emergency resection due to symptoms of the primary tumor. * Presence of extrahepatic metastatic disease confirmed at the time of resection or diagnosis. * High surgical risk defined as an ASA risk score greater than 3. * At least 10 cases performed by the invited center during the study period. * Incomplete data or follow-up of less than 6 months.
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What it tests

  • Data collection
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Where

1 site
SC Chirurgia Generale
Alessandria, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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