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Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic

Recruitingn/aAges any - anyAllCharles University, Czech Republic
NCT07274046 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic. The aim is to better understand how individuals recover from TBE, which symptoms may persist after the infection, and which patients may require additional support during their recovery. Participants are examined several times after hospital discharge (at 2-4 weeks, 3 months, 6 months, and 12 months) to observe changes in symptoms, functional status, and daily activities. Follow-up assessments include evaluation of common post-infection problems such as tiredness, headaches, memory or concentration difficulties, sleep issues, or limb weakness. Symptoms lasting for several months are categorized as post-encephalitic syndrome (PES). The study also assesses how TBE affects daily functioning, school and work performance, and overall quality of life using quest

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📋 Eligibility rules (as published)
Inclusion Criteria: * Hospitalization due to suspected central nervous system (CNS) infection. * Laboratory-confirmed TBE, defined as: the presence of CNS symptoms and cerebrospinal fluid pleocytosis (\>5 × 10⁶/L) and TBEV IgM and IgG seropositivity in serum, or detection of TBEV IgM in CSF in previously vaccinated individuals. * All age groups (children and adults). * Ability to participate in scheduled follow-up (in person or via telephone). * Informed consent provided by the patient or legal guardian (for minors). Exclusion Criteria: * Alternative diagnosis explaining the CNS symptoms * Missing essential clinical or laboratory data required to confirm TBE or assess outcomes. * Refusal or inability to provide informed consent. * Inability to complete follow-up assessments, including situations where reliable contact cannot be maintained. * Coexisting severe neurological disorder unrelated to TBE that prevents meaningful evaluation of sequelae (e.g., advanced neurodegenerative disease, severe preexisting motor disability).
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What it tests

  • No intervention
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Where

4 sites
Ostrava University Hospital
Ostrava, Czechia
Pardubická nemocnice
Pardubice, Czechia
Bulovka University Hospital
Prague, Czechia
České Budějovice Hospital
České Budějovice, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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