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Timing and Dose of Fluid Deresuscitation in Critically Ill Patients

Recruitingn/aAges 18 Years - anyAllAcademisch Medisch Centrum - Universiteit van Ams…
NCT07275658 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these determinants, and (3) differences in metabolic profiles for a more personalized approach of deresuscitation. This study is a multicenter, prospective, observational cohort study in critically ill patients. This study will include ICU patients who have a clinical indication for deresuscitation as set by the treating physician. Clinical, ultrasound and laboratory values will be collected and used for analysis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Admission to one of the participating ICUs; * Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay. Exclusion Criteria: * Age below 18 years old; * Major cardiac shunts; * Moderate to severe aortic regurgitation; * Morbid Obesisty (BMI \>40); * POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease); * PLR or modified form of PLR impossible (i.e. ECMO); * Transfer from another ICU; * Previous inclusion in this study; * Patients who are moribund or facing the end of life; * Opt out.
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What it tests

  • Not listed
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Where

2 sites
OLVG
Amsterdam, Netherlands
Amsterdam UMC
Amsterdam, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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