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Brain-Stomach Circuits in Chronic Nausea

RecruitingNAAges 21 Years - 60 YearsAllDavid Levinthal
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are: * What are the best brain sites to influence the stomach? * What are the effects of different stimulation patterns on stomach activity? * Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea? Researchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen. Participants will: * Visit the clinic at least once, and for up to 9 times more over the course of several months. * Receive TMS while sitting in a chair similar to a dentist's chair. * Drink water or consume a test meal during each study visit.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report. Exclusion Criteria: * body mass index (BMI) \> 30 * pregnancy or intention to become pregnant * past or present chemotherapy * diagnosis of gastric (stomach) cancer * any kind of gastric (stomach) surgery * current use of GLP-1 receptor agonists (e.g. Ozempic, Trulicity) * medications which significantly lower seizure thresholds (e.g. bupropion (Wellbutrin), fluoxetine (Prozac), or tramadol (Ultram)) * implantable devices, such as a pacemakers or nerve stimulators * history of head injury that required hospitalization, metal in the skull, or neurologic disease such as stroke, history of seizures or history of syncope (fainting or passing out) * neurodegenerative disease (Multiple Sclerosis, Parkinson's or Alzheimer's Disease) * ongoing psychosis or altered cognitive status status (e.g. hearing sounds or seeing visions that are not there, or feeling confused or suffering from memory lapses) * history of cardiovascular (i.e., heart attack), pulmonary (i.e., need for supplemental oxygen), or endocrine disease (e.g. diabetes) * current enrollment in another study using Transcranial Magnetic Stimulation (TMS) * current use of drugs such as amphetamines, methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or drinking 3 or more alcoholic drinks per day * For healthy subjects only: chronic history of gastrointestinal symptoms (e.g., nausea, indigestion, bloating, abdominal pain) * For CNVS subjects only: diagnosis of gastric motility disorder (e.g. gastroparesis/slow stomach emptying) or history of bowel obstruction (i.e., chronic partial small bowel obstruction)
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What it tests

  • Transcranial Magnetic Stimulation, TMS
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Where

1 site
University of Pittsburgh Medical Center
Pittsburgh, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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