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Promoting Recovery After Brain Injury Using Focused Ultrasound

RecruitingNAAges 18 Years - 79 YearsAllMassachusetts General Hospital
NCT07277309 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Brain injury resulting in DoC diagnosis, following international guidelines * At least 18 years of age * Legally authorized representative (surrogate) available to consent Exclusion Criteria: * History of neurological disorder other than the brain injury * Metal implant or other condition precluding MRI * Manifest continuous spontaneous movement (which would prevent safe/successful MRI) * Participation in concurrent therapeutic study * Pregnancy
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What it tests

  • Low-intensity focused ultrasound
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Where

2 sites
Massachusetts General Hospital (The General Hospital Corp.)
Boston, United States
Spaulding Rehabilitation Hospital Corporation, Inc.
Cambridge, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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