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โ† Trials
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Brain Stimulation in Long COVID

RecruitingNAAges 18 Years - anyAllAmsterdam UMC, location VUmc
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In plain words

What the trial is, and whether it could suit you

Cognitive problems and severe fatigue are two frequently occurring symptoms in long COVID, also known as Post-Covid Condition or Post-Acute Sequelae of COVID-19 (PASC), and their causes are currently unknown. Previous studies have shown reduced blood flow and increased inflammation in the brains of people with PASC. These brain processes are related to fatigue and cognitive problems. In other conditions, these disrupted brain processes have been treated safely and successfully with non-invasive brain stimulation. This may offer an effective treatment for people with PASC. The main goal of this clinical trial is to see whether non-invasive brain stimulation called repetitive transcranial magnetic stimulation (rTMS) can reduce fatigue in adults with PASC who also have trouble concentrating. rTMS uses short magnetic pulses on the scalp to gently stimulate a small brain area. In this study

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Meet the World Health Organization (WHO) definition of long COVID. * Aged 18 years or older. * Severe fatigue, defined as a score โ‰ฅ35 on the Checklist Individual Strength (CIS) fatigue subscale. * Significant cognitive complaints, defined as a score โ‰ฅ18 on the CIS concentration subscale. * Commitment to actively undergo rTMS * Ability to attend the study site regularly for treatment sessions. * Capacity to provide written informed consent. Exclusion Criteria: * Prior rTMS treatment or current intensive/experimental treatment for long COVID. * History of epilepsy or first-degree family history of epilepsy. * Recent initiation or dosage change of psychotropic medication (less than six weeks for psychotropic medication including antidepressants and antipsychotic drugs, less than two weeks for benzodiazepines). Medication doses must remain stable during the study. * Other active concurrent pharmacological treatments for post-covid symptoms * Contraindications to MRI scanning (e.g., non-removable metallic implants, severe claustrophobia). * Presence of a cochlear implant. * Neurological disorders such as multiple sclerosis or other neurodegenerative conditions. * Pregnancy. * Known brain lesions or ischaemic scars influencing seizure threshold. * Severe uncontrolled migraines. * Severe cardiovascular disease * Raised intracranial pressure. * High alcohol consumption (males/females: 21/14 units per week) or use of epileptogenic drugs. * Severe sleep deprivation at the time of treatment.
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What it tests

  • Repetitive Transcranial Magnetic Stimulation
  • Sham device
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Where

1 site
Amsterdam UMC
Amsterdam, Netherlands
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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