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Enhancing Management Algorithms for Children Conceived Via Assisted Reproductive Technologies

Recruitingn/aAges 0 Months - 3 YearsAllKazakhstan's Medical University "KSPH"
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In plain words

What the trial is, and whether it could suit you

Research Methods and Ethical Issues 1. Main Scientific Questions and Hypotheses of the Project The primary objective of this project is to investigate the impact of advanced ART methods on the health status of children. The central scientific questions being addressed include: What are the consequences of ICSI and FET on the physical, cognitive, and reproductive health of children? The underlying hypothesis posits that children conceived by advanced ART methods may present with health indicators that deviate from the established norms. 2. Description of the Experiments Research Methods: To achieve the goals of the study, the following stages are anticipated: 1. Retrospective Analysis of Anamnestic Data: This stage involves studying the relationship between the physical status and morbidity structure of 300 children under the age of three, who were conceived by advanced ART method

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📋 Eligibility rules (as published)
Inclusion Criteria: For children: * Born as a result of an ART program (IVF, ICSI, FET, or Fresh-ET). * Age at the time of assessment: from birth up to 36 months. * Availability of complete perinatal and medical documentation, including ART cycle characteristics and neonatal outcomes. * Informed consent provided by parents or legal guardians for participation in the study and for biological sample collection (where applicable). For mothers: * History of pregnancy achieved through ART within the territory of Kazakhstan. * Availability of data on pharmacological treatment before and during pregnancy (e.g., hormonal therapy, antithyroid drugs, vitamins, micronutrients). * Willingness to provide anamnestic and perinatal information, and consent for access to medical records. For fathers (in ICSI subgroup): * Documented infertility factor necessitating ICSI. * Agreement to provide relevant medical history and participate in comparative analyses (e.g., endocrine or reproductive parameters of father-son pairs).
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What it tests

  • Inhibin B
  • Anti-Müllerian Hormone (AMH)
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Where

1 site
Международный клинический центр репродуктологии Persona
Almaty, Kazakhstan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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