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Hemodiafiltration Versus Hemodialysis in Older People

RecruitingNAAges 85 Years - anyAllAUB Santé
NCT07278973 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF). Patients will receive the treatment over two periods: if period 1 is HD then period 2 will be HDF. Every patient will be his/her own control, this is why it is called cross-over. Each period will last three months. Between the two periods, patients will receive a traditional low-flux hemodialysis. These two techniques are widely used worldwide and their side-effects are well-known and do not put the patients at risk. HDF has been shown to improve survival in patients with a mean age of 58 years. But a previous study from the investigators' group showed that HDF causes a prolonged recovery time in older patients. This randomized trial aims to elucidate this quest

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📋 Eligibility rules (as published)
Inclusion Criteria: * Signed and dated informed consent * Age \>84 years * Diagnosed with kidney failure * On maintenance hemodialysis \>3months * Willing to have a dialysis session of 3.5 to 4-hour duration, three times a week * Has a reliable vascular access * Is covered by the health insurance Exclusion Criteria: * Patients with cognitive impairment (assessed with a mini-test if needed) * Hospitalized at inclusion * Have difficulties with French speaking * Terminally ill with life expectancy\<3 months * With active cancer
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What it tests

  • High-flux hemodialysis
  • Hemodiafiltration
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Where

4 sites
AUB Santé
Bretagne, France
AIDER
Grabels, France
ECHO
Le Mans, France
Aura Paris
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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