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Brain-lung Interaction During Acute Respiratory Failure

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT07279831 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute hypoxemic de novo respiratory failure (AHRF) is a common cause of admission to the intensive care unit (ICU). Its main cause is community-acquired pneumonia. Prevention of intubation relies, among other things, on high-flow nasal canulae (HFNC). However, approximately 40% of patients are intubated despite HFNC. Our team has developed measurements derived from electroencephalograms (EEG) and near-infrared spectroscopy (NIRS) that enable the study of brain-ventilation interactions. To date, these tools have been studied exclusively in intubated patients. the investigators now wish to study them in non-intubated patients. The objective of this study is to investigate the relationship between the brain and lungs in adult patients admitted to the intensive care unit for acute hypoxemic respiratory failure and for whom the attending physician has decided to initiate HFNC. Before and o

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📋 Eligibility rules (as published)
Inclusion Criteria: * \- Age ≥ 18 years * Admitted to the intensive care within the last 48 hours * De novo acute hypoxemic respiratory failure with an indication for high-flow nasal cannula (HFNC), defined by the combination of the following three criteria: * Tachypnea \> 25 breaths/min or labored breathing * PaO2 (partial pressure of oxygen ) /FiO2 ( fraction of inspired oxygen ) ≤ 200 mmHg * Unilateral or bilateral alveolar opacities on chest X-ray * Decision by the attending physician to initiate HFNC treatment * After information, the patient or next of kind did not refuse to participate (according to the French law, written informed consent is waived) Exclusion Criteria: * \- Exacerbation of an underlying chronic respiratory disease * Acute cardiogenic pulmonary edema indicating non-invasive ventilation (NIV) * Hypercapnia \> 45 mmHg indicating NIV * Glasgow Coma Scale \< 13 * Imminent intubation * Underlying central neurological disease likely to alter EEG signals * Pregnancy or breastfeeding * Lack of health insurance coverage * Patient under legal protection
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What it tests

  • EEG/NIRS/EMG
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Where

2 sites
Médecine Intensive - Réanimation, Hôpital Pitié Salpêtrière
Paris, France
Service de Médecine Intensive et Réanimation, Hôpital Pitié Salpêtrière
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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