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Aphasia Physical EXercise Study: Randomized Trial

RecruitingNAAges 18 Years - 80 YearsAllUniversity of California, Berkeley
NCT07281313 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is: • Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and/or psychosocial domains? Participants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting. Outcome measures will be

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aphasia following ischemic or hemorrhagic stroke * Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \< 93.8 at study intake) * At least 6 months from the last stroke * Proficient in English before the stroke * At least 8 years of education * Between the ages of 18 and 80 * Independent with ambulation without a device (single-point cane accepted) * Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider. Exclusion Criteria: * Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse * Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing * Self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise
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What it tests

  • High-intensity physical exercise
  • Low-intensity physical exercise
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Where

4 sites
University of California, Berkeley
Berkeley, United States
California State University, East Bay
Hayward, United States
University of San Francisco
San Francisco, United States
University of California, San Francisco
San Francisco, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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