🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive

Recruitingn/aAges 40 Years - anyAllUniversity of Nottingham
NCT07281651 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia). Pain is often not directly related to the degree of muscle or joint damage. Adaptations of the central nervous system (brain, spinal cord and nerves) often occur in chronic musculoskeletal conditions and can influence how we feel pain (central pain hypersensitivity). Pain can impact on muscle activity and movement. Muscle activity is also governed by nerve signals from the central nervous system (neural drive). The goal of this cross-sectional observational study is to investigate whether chronic musculoskeletal pain is associated with altered nerve signalling (neural drive) to skeletal muscles in adults 40 years or over with chronic knee pain, fibromyalgia and healthy pain free voluntee

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: Knee pain group * History of knee pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months Fibromyalgia group * Fibromyalgia diagnosis (participant self-reporting a previous diagnosis by a clinician) * Pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months Control group \- Pain free individuals without known osteoarthritis Exclusion Criteria: * BMI\>35 * Body weight of 250kg or higher * Pregnancy (women) * Inability to give consent * Inability to meet the requirements of clinical assessment * Performed strenuous physical exercise in the past 24 hours prior to testing * Consumed alcohol on day of testing * Consumed caffeine on day of testing
💊

What it tests

  • Central Pain Hypersensitivity
📍

Where

1 site
University of Nottingham Graduate Entry Medicine and Health, Royal Derby Hospital, Uttoxeter Road, Derby
Derby, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy