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Focal or Radical Therapy: a Lesion-based Molecular Evaluation in Prostate Cancer

RecruitingNAAges 21 Years - anyMaleSingapore General Hospital
NCT07282808 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Focal therapy (FT) is a new approach to treating localized prostate cancer. Instead of treating the entire prostate, it targets only the cancerous areas while preserving healthy tissue. This helps reduce side effects like urinary, sexual, and bowel problems. In a prospective observational expansion of a phase II clinical trial (ProAMFocal), 80% of patients with small, localized prostate cancers treated with FT had no cancer recurrence at one year, and 70% at 3 years after treatment. The investigators studied the genetic makeup of each cancer, and found that certain genetic markers and cancer subtypes were better at predicting recurrence than standard clinical measures. Based on this, the investigators are launching the FLAME-PC trial. In this study, all patients who qualify for FT will first undergo genetic profiling of their cancer. Patients with favorable profiles (low risk based on

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📋 Eligibility rules (as published)
Inclusion Criteria: * Prostate Adenocarcinoma * Grade Group 2-4 * MRI lesion size ≤3ml for single lesions ≤1.5ml for 2 lesions * no gross EPE * assessed to be completely ablatable with margin with focal therapy. Exclusion Criteria: * Grade Group 5 cancer * gross EPE * multifocal (\>2) clinically significant prostate cancer * unablatable location (very apical, basal tumors, or otherwise determined by procedurist).
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What it tests

  • Molecular Evaluation for Risk of Recurrence after FT
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Where

1 site
Singapore General Hospital
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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