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A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients

RecruitingEARLY Phase 1Ages 18 Years - anyAllMarissa Lobl
NCT07286318 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Organ Transplant Recipients This study is designed to evaluate whether a topical 5% niacinamide cream can help prevent skin cancer in organ transplant recipients. Individuals who have received an organ transplant have a much higher risk of developing precancerous skin growths and skin cancers because of long-term immune-suppressing medications. Although sunscreen is an important part of sun protection, additional preventive approaches are needed. Early research suggests that niacinamide may help protect the skin, and this trial will examine whether a topical formulation provides benefit in this high-risk group. The study will test whether daily use of topical 5% niacinamide reduces the number of actinic keratoses over 6 and 12 months and whether it decreases the development of new keratinocyte cancers

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📋 Eligibility rules (as published)
Inclusion Criteria: Age ≥18 History of solid organ transplantation At least 5 AKs in the past year or prior history of skin cancer Participants are willing to continue using SPF30 sunscreen from their own supply Exclusion Criteria: Known allergy to niacinamide or sunscreen components Eczema or other skin conditions for which niacinamide is contraindicated
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What it tests

  • Topical niacinamide 5% cream
  • Sunscreen
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Where

2 sites
UPMC Falk Dermatology
Pittsburgh, United States
UPMC St Margarets Dermatology
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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