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Glycyrrhetinic Acid and Acute Irritant Dermatitis

RecruitingNAAges 18 Years - anyAllUniversity of Split, School of Medicine
NCT07286487 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Irritant dermatitis is one of the most common inflammatory skin disorders, caused by exposure to external substances that induce inflammation and immune activation. Standard management includes avoidance of irritants, restoration of the skin barrier using emollients, and the application of anti-inflammatory drugs such as topical corticosteroids. However, due to the risks associated with long-term corticosteroid use, there is an interest in developing emollient formulations enriched with bioactive compounds possessing anti-inflammatory properties. Among those promising compounds is glycyrrhetinic acid. 18ฮฒ-Glycyrrhetinic acid, a bioactive component of licorice root extract, exhibits potent anti-inflammatory and antioxidant effects. Topical application has demonstrated beneficial outcomes in conditions such as atopic dermatitis, acne, pruritus, and UVB-induced skin damage. Its proposed me

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Healthy adult participants aged 18 years or older, of any sex. * Intact, healthy skin at the test sites. * No use of systemic or topical corticosteroids, immunomodulators, or antihistamines within the previous three months. * No use of topical emollients on the test sites within the previous seven days. Exclusion Criteria: * Pregnant women, women suspected of being pregnant, and breastfeeding women. * Non-compliance with the study protocol. * Voluntary withdrawal or personal decision not to continue participation.
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What it tests

  • SLS induced irritation
  • No Treatment
  • Placebo
  • Low Dose Glycyrrhetinic Acid Formulation
  • High Dose Glycyrrhetinic Acid Formulation
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Where

1 site
University of Split School of Medicine
Split, Croatia
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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