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Impact of Guided Biofilm Therapy on Epithelial and Mesenchymal Biomarkers in Periodontitis Patients

RecruitingNAAges 18 Years - anyAllUniversity of Baghdad
NCT07286916 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to investigate the clinical and biochemical effects of the guided biofilm therapy protocol as an alternative to the conventional non-surgical periodontal therapy in patients with periodontitis. The main question it aims to answer is: Does the guided biofilm therapy (GBT) protocol have an impact on gingival crevicular fluid (GCF) epithelial and mesenchymal biomarkers in patients with periodontitis? All patients will be instructed to brush their teeth twice daily and will be supplied with the same type of toothpaste and toothbrush, with suitable interdental aids. All patients will be instructed to attend again after 7 days. At baseline, full-mouth periodontal charting and radiographs will be obtained and after 1-hour, GCF samples will be collected from both test and control groups. Sites allocated to control group will undergo supragingival debridement

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adult subjects (\>18 years). 2. Subjects are not currently under active periodontal therapy or joining other trial in the last 3 months. 3. Patients must be diagnosed with generalized unstable periodontitis with bilateral, symmetrical distribution of PPD ≥ 4mm and positive BOP. \- Exclusion Criteria: 1. Patients not diagnosed with periodontitis. 2. Patients consuming antibiotics. 3. Regular users of nonsteroidal anti-inflammatory drugs (NSAIDs). 4. Patients receiving periodontal treatment 3-months prior to the study. 5. Pregnant or mothers in a breastfeeding period. 6. Third molars and teeth with furcation involvement. 7. Patients taking antioxidant supplements. 8. Patients with heavy calculus that would prevent PerioPaper strips entrance to the periodontal pocket. 9. Patient with pulmonary diseases and with a history of allergy to erythritol. 10. Patients not willing to participate. -
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What it tests

  • Root surface debridement
  • Guided Biofilm Therapy
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Where

1 site
College of Dentistry, University of Baghdad
Baghdad, Iraq
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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