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Effects of Photobiomodularion on Brain Connectivity and Cognitive Function in Cognitive Impairment

RecruitingNAAges 55 Years - anyAllUskudar University
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if transcranial photobiomodulation (t-PBM), a light-based brain therapy, can help improve memory and cognitive skills in older adults with amnestic mild cognitive impairment (aMCI). This condition involves memory problems that are greater than normal aging and may increase the chance of developing Alzheimer's disease. The main questions this study aims to answer are: 1. Does t-PBM, when used together with cognitive training, improve memory and cognitive skills? 2. Does t-PBM change how certain brain areas communicate with each other, especially in the default mode network (DMN)? Researchers will compare: t-PBM plus cognitive training to sham (inactive) t-PBM plus the same cognitive training to see if the active light treatment leads to better cognitive improvement and healthier brain activity. Participants will: * Provide a blood sample s

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age 55 years or older * Diagnosis of amnestic Mild Cognitive Impairment (aMCI) Exclusion Criteria: * Presence of a neurological disorder * Presence of a severe psychiatric disorder * Having a pacemaker or other implanted medical device that is not MRI-compatible
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What it tests

  • Active transcranial Photobiomodulation
  • sham transcranial Photobiomodulation
  • Cognitive Rehabilitation
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Where

2 sites
NPIstanbul Brain Hospital
Istanbul, Turkey (Türkiye)
Uskudar University, Faculty of Medicine
Istnabul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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