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Neural Mechanisms of Temporal Interference Stimulation on Improving Social Reward Function in Depression

RecruitingNAAges 16 Years - 65 YearsAllShanghai Mental Health Center
NCT07287878 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Major depressive disorder (MDD) is a mood disorder characterized primarily by low mood, diminished interest, and reduced energy. Traditional views considered depression a non-degenerative condition; however, recent epidemiological studies have revealed its significant association with impaired social functioning. Data indicate that 59.3% of patients with depression experience social dysfunction of varying severity \[1\], particularly manifesting as difficulties in social interaction and relationship maintenance \[2\]. Therefore, investigating the mechanisms underlying social dysfunction is of great importance for promoting functional recovery in MDD, and dysfunction within the social reward system may represent a core factor, though the specific neural mechanisms remain unclear. The ultimate goal of understanding the neural mechanisms underlying social reward impairment in depressed pat

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📋 Eligibility rules (as published)
Inclusion Criteria: * 16-60 years old; * Meeting with the criteria of major depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5; * Scored 20 or higher on the Hamilton's Depression Scale with 24 items (HAMD-24); * With enough audio-visual ability and comprehensive ability to accomplish the visits; * Be necessary and suitable to accept the treatment of antidepressants; * Scored less than 14 on Hamilton's Anxiety Scale (HAMA) and scored less than 14 on the Hypomania Symptom Checklist-32 (HCL-32); * With 2 or more atypical symptoms including significant weight gain or increase in appetite, hypersomnia, leaden paralysis, and a long-standing pattern of interpersonal rejection sensitivity that results in significant social or occupational impairment. Exclusion Criteria: * Severe medical or neurological problems; * Previous mania or hypomania episodes; * Female patients who are pregnant, planning to be pregnant or breastfeeding; * Actively suicide ascertained by research psychiatrist or 3rd item of HAMD scored≥3(suicidality); * Had ECT, MECT or rTMS in the past 6 months; * Experienced severe personality disorder, mental retardation, anorexia/ bulimia nervosa.
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What it tests

  • Temporal Interference Simulation(TIS)
  • Temporal Interference Stimulation(TIS)
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Where

1 site
Shanghai Mental Health Center
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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