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Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function

RecruitingNAAges any - anyAllAristotle University Of Thessaloniki
NCT07289061 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized study tests whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults at the earliest stages of dementia-related decline. About 128 participants with Subjective Cognitive Decline or Mild Cognitive Impairment will be enrolled. Half will be randomized to the Positive Psychology program and half to Treatment As Usual (TAU). The program consists of weekly, small-group online sessions for \~24 weeks plus brief home practices. All participants (both arms) will complete questionnaires and cognitive tests at baseline, during treatment, post-treatment, and 9-month follow-up. Primary question: Do participants receiving the Positive Psychology program show better cognitive and brain-function outcomes than TAU at post-treatment and at 9 months? Secondary question: Are effects larger for SCD than MCI? No medicines are used and risk

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📋 Eligibility rules (as published)
Inclusion Criteria -Documented diagnosis of Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI) according to clinical evaluation and site standard criteria. Exclusion Criteria * Diagnosis of dementia (major neurocognitive disorder) or other major neurocognitive disorder that is moderate or severe. * Major psychiatric disorder currently unstable or untreated (e.g., major depression with psychotic features, bipolar disorder, schizophrenia). * Neurological conditions that affect cognition. * Uncorrected hearing or vision problems that prevent participation in assessments or online sessions. * Concurrent participation in another interventional study targeting cognition or wellbeing during the study period.
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What it tests

  • Positive Psychology Intervention
  • Treatment as usual (TAU)
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Where

1 site
Aristotle University of Thessaloniki
Thessaloniki, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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