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Inflammation Severity and miRNA-126 in Trauma

Recruitingn/aAges 18 Years - anyAllMelike Cengiz
NCT07291908 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Trauma triggers a complex immune response intended to eliminate danger signals and restore physiological balance. Early post-traumatic inflammation is primarily initiated by damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). In patients with severe trauma, dysregulated inflammation increases susceptibility to infection, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and mortality. The lungs are particularly vulnerable, and excessive inflammatory activation may lead to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), conditions characterized by increased vascular permeability, alveolar epithelial injury, surfactant dysfunction, and impaired gas exchange. Pro-inflammatory cytokines, activated neutrophils, reactive oxygen species, and proteases contribute to endothelial and epit

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📋 Eligibility rules (as published)
Inclusion Criteria: Adults aged 18 years or older. Patients monitored and treated for trauma in the anesthesia intensive care units of Akdeniz University Faculty of Medicine. Exclusion Criteria: Patients younger than 18 years. Patients with concomitant thoracic trauma. Presence of active infection prior to trauma. Patients not admitted to the ICU within the first 24 hours after trauma. Patients who remain in the ICU for less than 72 hours following trauma. Current use of steroids, chemotherapy, or antibiotic therapy prior to ICU admission. Patients with immunodeficiency. Patients who are in shock prior to or during ICU admission.
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What it tests

  • Not listed
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Where

1 site
Akdeniz University Hospital
Antalya, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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