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Nerve Grafting Using MATRIderm® in Traumatic Digital Nerve Injuries: a Randomized, Single-center, Controlled Study

RecruitingNAAges 16 Years - 75 YearsAllCentre Hospitalier Universitaire de Nice
NCT07292415 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hand and wrist injuries are very common, with nearly 2 million cases each year in France. Many injuries involve cuts that damage important structures such as nerves, tendons, blood vessels, bones, or joints. About 12.5% of hand wounds affect nerves, which can cause numbness, pain, or abnormal nerve growths called neuromas. Patients may also experience unusual sensations or intolerance to cold. The usual treatment for a cut nerve is to carefully stitch it back together. Sometimes, additional techniques can be used to help the nerve heal better and reduce scarring. One technique, called nerve wrapping, involves surrounding the damaged nerve with a small protective tube to support its repair. This study is testing the use of MatriDerm®, a collagen-elastin matrix originally used to help skin heal. MatriDerm® acts like a scaffold, supporting tissue repair and controlling scar formation. Its

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patient aged 16 to 75 2. Patient with a palm or finger wound with sensory nerve damage (partial \>50% or total) 3. Indication for repair by direct suture in the operating room 4. Possibility of attending a follow-up visit after 1 year 5. Patient affiliated with a social security system 6. Patient who has given their written consent after receiving written and oral information Exclusion Criteria: 1. Pre-existing sensory disorders 2. History of nerve damage in the affected hand 3. Known hypersensitivity to bovine proteins 4. Active infection in the affected hand 5. Patient protected by law under guardianship or curatorship, or unable to participate in a clinical study MATRINERVE 24-PP-12 Version No. 1.0 dated July 22, 2025 Page 8 of 40 clinical trial under Article L. 1121-16 of the French Public Health Code 6. Pregnant or breastfeeding women of childbearing age
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What it tests

  • Standard peripheral nerve repair under regional anesthesia with magnification; epineural sutures placed, followed by 2-week immobilization if needed.
  • Peripheral nerve repair under regional anesthesia with epineural sutures; nerve wrapped along its length with 1 mm MatriDerm® collagen-elastin matrix before standard skin closure.
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Where

1 site
CHU de Nice
Nice, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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