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Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

RecruitingPhase 3Ages 35 Years - 80 YearsAllAmgen
NCT07293260 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 35 to ≤ 80 years. * Lp(a) ≥ 200 nmol/L during screening. * Angiographic evidence of coronary artery disease in at least one major epicardial vessel on screening CCTA. * History of myocardial infarction (presumed type 1 event due to plaque rupture/erosion) and/or coronary revascularization by percutaneous coronary intervention. Exclusion Criteria: * History of coronary artery bypass graft (CABG). * Moderate to severe renal dysfunction. * Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \> 3 x upper limit of normal (ULN), or total bilirubin (TBL) \> 2 x ULN during screening. * History of hemorrhagic stroke. * History of major bleeding disorder. * Planned cardiac surgery or arterial revascularization. * Severe heart failure. * Current, recent, or planned lipoprotein apheresis. * Previously received ribonucleic acid therapy specifically targeting Lp(a).
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What it tests

  • Olpasiran
  • Placebo
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Where

40 sites
Bridgeport Hospital
Bridgeport, United States
Jacksonville Center for Clinical Research
Jacksonville, United States
Midwest Heart and Vascular Specialists
Overland Park, United States
Flourish Bowie
Bowie, United States
Montefiore Medical Center - Bronx
Philadelphia, United States
Vital Heart and Vein
Humble, United States
Advara HeartCare Wesley
Auchenflower, Australia
University of The Sunshine Coast Clinical Trials, Sippy Downs
Sippy Downs, Australia

…and 32 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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