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Impact of Cardio-Selective Beta-Blockers on Infarct Size After Acute Myocardial Infarction

Recruitingn/aAges 18 Years - 80 YearsAllAristotle University Of Thessaloniki
NCT07293832 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Introduction: The effect of intravenous beta-blockers on the extent of the necrotic area, after primary percutaneous transluminal coronary angioplasty (PTCA), for acute myocardial infarction is not well established. Purpose: The present study aims to investigate, whether the early intravenous administration of landiolol, a highly cardioselective b-blocker, reduces the extent of the necrotic area after ST-elevation myocardial infarction (STEMI). Methods: This prospective observational cohort study will enroll patients presenting with STEMI, who undergo primary PCI and receive either intravenous landiolol or standard oral ฮฒ-blocker therapy, in accordance with current European Society of Cardiology (ESC) guidelines. Eligibility will be determined by predefined inclusion and exclusion criteria. Treatment selection will be based solely on the clinical judgment of the attending cardiologist,

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 80 years * Patients with electrocardiogram showing ST-segment elevation โ‰ฅ2 mm in 2 or more contiguous leads for more than 30 minutes * Estimated time from symptom onset to reperfusion โ‰ค12 hours * Patients scheduled to undergo primary angioplasty * Patients who have signed a consent form Exclusion Criteria: * Patients receiving chronic medication with beta-adrenergic blockers * Patients with a previous myocardial infarction * Persistent systolic blood pressure \<90 mmHg * Persistent heart rate \<55 beats per minute * Patients with Killip class III (acute pulmonary edema) or IV (cardiogenic shock) on initial examination * 12-lead electrocardiogram with PR interval \>200 milliseconds * 12-lead electrocardiogram showing second- or third-degree atrioventricular block * Bronchospasm requiring bronchodilator treatment * Possible pregnancy or postpartum period * Inability or refusal to sign the consent form
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What it tests

  • Not listed
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Where

1 site
Hippokration General Hospital of Thessaloniki
Thessaloniki, Greece
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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