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Spastic Myopathy in Adults With Cerebral Palsy

RecruitingNAAges 18 Years - anyAllNeuroloco
NCT07293988 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cerebral palsy (CP) is indeed the result of a central neurological lesion, but it also involves a lesser-known muscular condition that we refer to as spastic myopathy. This condition is likely the consequence of relative immobilization and underuse of the muscles in the affected limbs and, through a vicious cycle, it in turn plays a major role in movement difficulties. Among the muscles involved are the plantar flexors, whose extensibility decreases from the earliest years of the child's life. The BIOTN research team (UR7377; Université Paris-Est Créteil; Dr M. Pradines, Prof. J.-M. Gracies, CHU Henri Mondor, Créteil), supported by the Fondation pour la Paralysie Cérébrale, is conducting a randomized controlled study aimed, on the one hand, at characterizing in these individuals the genetic, histological, radiological, mechanical, physiological, and clinical changes in the calf muscle,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Hemiparesis or diparesis resulting from a cerebral lesion occurring during the perinatal period (cerebral palsy). * Gastrocnemius extensibility XV1 \< 100° (XV1, Tardieu Scale). * Maximum barefoot walking speed (AT10) between 0.3 and 1.2 m/s. * Written informed consent to participate in the study. Exclusion Criteria: * Botulinum toxin injections in the medial gastrocnemius within less than 3 months prior to study inclusion. * Cognitive impairment preventing participation in the GSC program or in the study. * Patients under legal guardianship or conservatorship. * Known hemostasis disorders. * Hypersensitivity to allergens. * Presence of a metallic intraocular foreign body (accidental fragments or others), a pacemaker, a neurostimulator (pain treatment), a cochlear implant, or, more generally, any implanted electronic medical device that cannot be removed; presence of a metallic cardiac valve in the study participant.
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What it tests

  • Guided Self-rehabilitation Contract
  • Conventional therapy group
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Where

1 site
Maud Pradines
Créteil, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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